Comet Assay Demonstrates a Higher Ultraviolet B Sensitivity to DNA Damage in Dysplastic Nevus Cells Than in Common Melanocytic Nevus Cells and Foreskin Melanocytes

Dysplastic nevus (atypical nevus).

Atypical nevum (dysplastic) is considered an important factor associated with increased risk of developing cutaneous melanoma. It is believed that atypical nevi are precursor lesions of cutaneous melanoma. They may be present in patients with multiple melanocytic nevi (atypical nevus syndrome) or isolated and in small numbers in a non-familial context. The disease usually begins at puberty and ...

Spontaneous Change in a Common Melanocytic Nevus.

Mujer de 39 años, fototipo II de Fitzpatrick, con antecedentes de melanoma en 2 familiares de primer grado, en seguimiento dermatoscópico digital por síndrome de nevus displásico, que consultó por cambio brusco de aspecto y aparición de prurito, en una lesión en la espalda, de años de evolución, que permanecía estable hasta entonces. Negaba traumatismo previo. En la región lumbar izquierda pres...

An amelanotic dysplastic melanocytic nevus induced by vemurafenib.

Vemurafenib is a B-raf kinase inhibitor developed to treat metastatic melanoma in patients with the BRAF V600E mutation, which is found in 40% to 60% of patients with advanced melanoma. It acts by inhibiting the BRAF/MEK/ERK mitogenactivated protein kinase (MAPK) pathway at the BRAF/MEK step. Recent studies have reported that vemurafenib is associated with a 63% reduction in risk of death. Adve...

Atypical Mole (Dysplastic Nevus)

Dysplastic pointillist nevus.

BACKGROUND Three cases of pointillist nevus, which is a distinctive clinical type of benign melanocytic nevus with variegated pigment, have been described in the literature to date. OBSERVATIONS A 24-year-old man presented with an acquired melanocytic lesion composed of multiple tiny pigmented dots. Dermoscopy revealed multiple brown globules on a reddish skin-colored background, and histolog...